Pole « Bacterial Adaptation and Pathogenesis »

The Bacterial Adaptation and Pathogenesis division (BAP) comprises 10 Micalis teams  (BaPS, B3D, CPE, MicrobAdapt, Paroi, EpiMiC, GME, PIMs, ComBac, Phages) that collectively contribute to advancing our understanding of microbial behavior in the areas of food safety, host-pathogen interactions, and microbial adaptation mechanisms. Research within the BAP spans a broad spectrum of critical areas, addressing factors such as microbial establishment, intercellular communication, persistence, and the intricate dynamics of phage interactions. The teams study microorganisms with specific properties relevant to food production, particularly those that pose risks after ingestion. The research portfolio covers a wide range of topics, including pathophysiology, antibiotic resistance, biofilm emergent properties, and the epigenetic consequences of bacterial infections. Investigations are multifaceted, exploring the impact of cell walls on microbial interactions and the transition of bacteria from commensalism to pathogenesis. This holistic approach, incorporating cutting-edge molecular and genomic insights, allows these teams to address scientific challenges such as therapeutic innovation, microbiota dysbiosis, infectious risks, and the potential applications of bacteriophages in health and industry. Collectively, the work of the BAP teams sheds light on critical aspects of microbiology with the goal of improving infection prevention and therapeutic strategies to improve human and animal health in an evolving microbial landscape.
BAP Keywords: molecular mechanisms, genome, metabolism, adaptation, virulence, host response, immunity, epigenetics, pathobiomes, bacteriophages, cell wall, cell membrane, antibiotics and alternatives, quorum sensing, food matrix, biofilms. The head of the pole "Bacterial Adaptation and Pathogenesis" is Romain Briandet.